About the Journal of Hypertension and Cardiology
Advancing pathophysiological understanding of cardiovascular diseases through rigorous open access scholarship—connecting molecular mechanisms to clinical insights for researchers and practitioners worldwide.
Understanding Cardiovascular Disease at the Molecular Level
The Journal of Hypertension and Cardiology (JHC) (ISSN 2329-9487) is a peer-reviewed, open access publication dedicated to advancing the pathophysiological understanding of hypertension and cardiovascular diseases. JHC focuses on elucidating the molecular mechanisms, biomarkers, and cellular pathways that underlie cardiovascular pathology, providing a critical platform for mechanistic research that bridges basic science and translational investigation.
Hypertension affects approximately 30% of adults in developed nations and stands as a leading contributor to cardiovascular morbidity and mortality worldwide. Understanding the pathogenic mechanisms—from vascular remodeling and endothelial dysfunction to neurohormonal dysregulation and inflammatory cascades—is essential for identifying novel therapeutic targets and improving risk stratification strategies.
JHC publishes original research, comprehensive reviews, and methodological innovations that illuminate how cardiovascular diseases develop and progress at molecular, cellular, and systems levels. Our editorial commitment emphasizes scientific rigor, reproducibility, and the transparent dissemination of mechanistic insights that inform future intervention development.
The Journal of Hypertension and Cardiology is committed to three core objectives that define our publishing philosophy and community engagement:
- Advance Mechanistic Knowledge: Disseminate high-quality research that deepens understanding of cardiovascular pathophysiology, from molecular pathways to disease model validation.
- Foster Scientific Innovation: Encourage the development and validation of novel biomarkers, disease models, and mechanistic hypotheses that drive translational progress.
- Enable Research Collaboration: Connect researchers across disciplines—molecular biology, biochemistry, physiology, pathology—to facilitate mechanistic insight exchange and reproducible science.
JHC operates within a framework of ethical publishing standards, aligning with COPE guidelines and maintaining transparent peer review, conflict of interest disclosure, and data sharing policies. Our editorial board comprises international experts in cardiovascular pathophysiology who ensure rigorous assessment of methodological quality and scientific novelty.
JHC welcomes manuscripts that explore the fundamental biological processes underlying hypertension and cardiovascular diseases. Our scope emphasizes mechanistic understanding rather than clinical practice guidelines or patient management protocols.
Signal transduction pathways, gene expression regulation, epigenetic modifications, and protein interactions in cardiovascular pathogenesis.
Endothelial dysfunction, vascular smooth muscle remodeling, cardiomyocyte hypertrophy, apoptosis, autophagy, and cellular stress responses.
Identification and validation of molecular biomarkers for disease detection, progression monitoring, and mechanistic pathway elucidation.
Development and characterization of in vitro, ex vivo, and in vivo models that recapitulate cardiovascular disease mechanisms for mechanistic investigation.
Inflammatory cascades, immune cell involvement, cytokine networks, and inflammatory mediators in cardiovascular pathology.
Metabolic pathways, insulin resistance mechanisms, lipid metabolism, oxidative stress, and mitochondrial dysfunction in cardiovascular disease.
Vascular remodeling, arterial stiffness mechanisms, angiogenesis, endothelial progenitor cells, and vascular aging pathways.
Renin-angiotensin-aldosterone system, sympathetic nervous system activity, natriuretic peptides, and autonomic regulation mechanisms.
Genetic variants, genome-wide association studies, transcriptomics, proteomics, and multi-omics approaches to cardiovascular disease mechanisms.
The Journal of Hypertension and Cardiology accepts a diverse range of article types to accommodate the varied nature of mechanistic cardiovascular research:
- Original Research: Novel mechanistic findings from laboratory investigations
- Review Articles: Comprehensive syntheses of pathophysiological mechanisms
- Systematic Reviews: Evidence-based mechanistic pathway analyses
- Methodology Articles: New techniques for studying cardiovascular mechanisms
- Short Communications: Preliminary mechanistic observations
- Hypotheses: Mechanistic theories requiring experimental validation
- Mini-Reviews: Focused overviews of specific pathophysiological topics
- Data Reports: High-quality datasets supporting mechanistic research
- Letters to the Editor: Scientific discourse on published mechanisms
- Rapid Communications: Time-sensitive mechanistic discoveries
All submissions undergo rigorous peer review by experts in cardiovascular pathophysiology. Detailed guidelines for manuscript preparation, including reporting standards, ethics requirements, and formatting specifications, are available in our Instructions for Authors.
JHC employs a streamlined submission system designed to facilitate efficient manuscript handling while maintaining rigorous scientific standards. Authors may submit manuscripts through two convenient pathways:
- Online Submission: Via the manuscript submission portal for rapid processing and tracking
- Email Submission: Direct to [email protected] with complete manuscript package
Manuscripts should be prepared according to ICMJE guidelines, include structured abstracts (maximum 300 words), follow appropriate reporting standards (e.g., ARRIVE for animal studies), and provide complete ethics documentation including institutional review board approval for human subjects or animal welfare committee approval.
The editorial office acknowledges receipt within 72 hours and initiates peer review by at least two independent experts in cardiovascular pathophysiology. Reviewers assess methodological rigor, mechanistic novelty, reproducibility, and scientific significance. Authors receive constructive feedback aimed at strengthening manuscripts regardless of publication decision.
JHC operates as a fully open access journal, ensuring that mechanistic cardiovascular research reaches the widest possible scientific audience without subscription barriers. All published content is freely available immediately upon publication under Creative Commons licensing.
To sustain high-quality editorial operations, peer review infrastructure, and production services, JHC levies article processing charges (APCs) payable only after manuscript acceptance. The journal offers competitive pricing with potential waivers for authors from low-income countries and early-career researchers facing financial constraints.
Detailed information on APCs, waiver application procedures, and institutional agreements is available on our APC information page.
Advance Cardiovascular Pathophysiology Research with JHC
Whether you investigate molecular mechanisms, develop disease models, discover biomarkers, or explore cellular pathways, JHC provides a rigorous, open access platform for your mechanistic cardiovascular research.
